Get to know the project
SPARCLE is a European research initiative developing next-generation, miniaturized, battery-less implantable pulse generators for managing chronic and lifestyle-related diseases. By fusing bioelectronics, flexible materials, and AI-driven modeling, we aim to transform healthcare delivery and patient outcomes.
The Goal
SPARCLE stands for Small form factor implantable Pulse generAtoRs for Chronic and Lifestyle-related disease managEment.
The project aims to create a microelectronic chip and a small, flexible form factor for an implantable pulse generator. This technology will serve as a universal neuro-stimulator platform to be applied in treating chronic diseases such as neuro-based cancer treatments, severe migraines, and spinal cord injuries.
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Applications & Impact
The project specifically targets applications in three key areas:
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Severe migraines: Aiming to address an underserved market with significant demand for effective, minimally invasive solutions.
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Oncology: Developing neurostimulation therapies for cancer treatment, particularly pancreatic adenocarcinoma.
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Spinal cord injuries (SCI): Enhancing quality of life and reducing healthcare costs by restoring functions lost due to spinal cord injuries.
Technology & Innovation
Bioelectronic Medicine
Emerging medical approach using electrical pulses to precisely treat chronic diseases without drugs.
Ultrasound Neural Modulation
Precise, non-invasive nerve stimulation using focused ultrasound to improve therapy effectiveness.
Flexible Packaging Technologies
Soft, conformable protective materials enabling safe, miniaturized implants suited for long-term implantation.
Battery-less Wireless Powering
Innovative inductive energy transfer powering implants continuously without internal batteries.
Wearable Companions
External wearable units providing wireless power and real-time data communication with implants.
Biocompatible Polymer Coatings
Advanced conductive polymer layers reducing electrode impedance, enhancing safety and performance.
In-silico Modeling & Simulation
Computational platforms predicting device performance, optimizing treatment, and reducing clinical trial risks.
Meet the partners
Discover the innovative organizations driving the success of the SPARCLE-project. Each member brings unique skills and expertise to the table, ensuring top-notch results for our project.
Salvia BioElectronics
Project coordinator
Chronic migraine implant development
The Netherlands
Delft University of Technology
Bioelectronic implant research
The Netherlands
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IMEC
Integrated electronics (ASIC) development for implantable devices
The Netherlands
Reden BV
Reliability modelling through virtual prototyping
The Netherlands
Coherence Neuro
Highly miniaturized neural implant development
United Kingdom
Onward Medical Inc.
Implantable neurostimulator development for people with a spinal cord injury
Switzerland
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Eindhoven University of Technology
Closed loop neurostimulation
The Netherlands
Pezy Group
Wearable companion device development
The Netherlands
ZMT Zurich MedTech AG
In-silico therapy optimization
Switzerland
University of Cambridge
Polymer microelectrode research
United Kingdom
Patient-Centered Innovation
The SPARCLE Project: Revolutionizing chronic disease management through smart implantable neurotechnology
